Recently, the Zika virus epidemic has caused a setting of health emergency in Brazil. This event has mobilized several stakeholders to look at this reality - where women, men and children born with the marks of these diagnoses are differently affected - as one with vectors, illnesses and obscure diagnosis situations. Recalling this recent memory means summoning the political realms to demand the commitment to the health of the population in contexts of health emergencies and their repercussions in the daily life. Almost three years after the first diagnoses, the data collection from the Social and Economic Impacts of Zika virus infection in Brazil, carried out in Rio de Janeiro and Recife (Pernambuco State), covering the subjects and rural regions of both these capitals, is concluded. This research was coordinated by the Oswaldo Cruz Foundation (Fiocruz), the Aggeu Magalhães Institute (IAM), the National Institute of Women, Children and Adolescents Health Fernandes Figueira Fernandes Figueira (IFF), the Federal University of Pernambuco (UFPE) and the London School of Hygiene & Tropical Medicine. In Rio de Janeiro, the research was based on two prospective cohort studies. In Recife, subjects were from case-control studies on microcephaly, being the cohort based on health services (primary and specialized care) and children with congenital Zika syndrome.